Cancer Stem Cells and Metastasis

Decades of cancer research have led to substantial progress in the treatment of primary breast cancers. Despite of the advancement in this field, treating a metastatic disease has remained a mammoth task. One of the possible theories explaining metastatic disease involves the cancer stem cells (CSCs...

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Bibliographic Details
Published inProgress in Molecular Biology and Translational Science: Approaches to Understanding Breast Cancer Vol. 151; pp. 137 - 176
Main Authors Lakshmanaswamy, Rajkumar, Nandy, Sushmita
Format Reference Journal Article
LanguageEnglish
Published Netherlands 2017
Subjects
Breast cancer
Cancer cells
Cancer metastasis
Carcinogenesis
Cell adhesion
Cellular signal transduction
Epidermal growth factor receptors
Epithelial-Mesenchymal Transition
Extracellular matrix
Fibroblasts
Gene expression
Humans
Immunotherapy
Neoplasm Metastasis - pathology
Neoplastic Stem Cells - pathology
Stem cells
Tumor Microenvironment
epithelial-to-mesenchymal transistion-EMT
stem cells
breast cancer
metastasis
cytokines and chemokines
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Summary:Decades of cancer research have led to substantial progress in the treatment of primary breast cancers. Despite of the advancement in this field, treating a metastatic disease has remained a mammoth task. One of the possible theories explaining metastatic disease involves the cancer stem cells (CSCs). CSCs have been shown to be an integral part of solid tumors. The process of metastasis involves the fine orchestration between CSCs and other microenvironmental factors. This chapter will provide an overview about the process of metastasis and the interactive role of CSCs with the components of the microenvironment in each phase of the metastatic cascade.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1878-0814
DOI:10.1016/bs.pmbts.2017.07.007