A novel alkaloid from the seeds of Sophora alopecuroides L

A new cytisine-type alkaloid, along with five known alkaloids was obtained from the seeds of Sophora alopecuroides. Their structures were determined to be (−)-N-(2'-hydroxy-3',5'-di-tert-butyl-toluene)-cytisine (1), (−)-lupanine (2), (+)-matrine (3), (+)-sophoramine (4), (+)-lehmannin...

Full description

Saved in:
Bibliographic Details
Published inNatural product research Vol. 36; no. 7; pp. 1864 - 1869
Main Authors Rong, Zi-Jian, Gao, Xiao-Xu, Hu, Gao-Sheng, Yan, Ting, Jia, Jing-Ming, Wang, An-Hua
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.04.2022
Subjects
Alkaloids - chemistry
cytisine-type alkaloid
cytotoxicity activity
Humans
Seeds - chemistry
Sophora - chemistry
Sophora alopecuroides L
cytisine-type alkaloid
Sophora alopecuroides L
cytotoxicity activity
Online AccessGet full text

Cover

More Information
Summary:A new cytisine-type alkaloid, along with five known alkaloids was obtained from the seeds of Sophora alopecuroides. Their structures were determined to be (−)-N-(2'-hydroxy-3',5'-di-tert-butyl-toluene)-cytisine (1), (−)-lupanine (2), (+)-matrine (3), (+)-sophoramine (4), (+)-lehmannine (5) and (−)-sophocarpine (6). Their structures were established by NMR, ECD and HRESIMS data analyses. Their cytotoxicity effects against five human tumor cell lines were tested by MTT assay. Compound 1 has showed a wide range of cytotoxicity activities against varied tumor cells in vitro.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1824226