Detection of polyamines by an extended gate-type organic transistor functionalized with a carboxylate attached 1,3,4-thiadiazole derivative

• Published in: Journal of materials chemistry. C, Materials for optical and electronic devices Vol. 9; no. 35; pp. 1169 - 11697
• Main Authors: Asano, Koichiro, Sasaki, Yui, Zhou, Qi, Mitobe, Riho, Tang, Wei, Lyu, Xiaojun, Kamiko, Masao, Tanaka, Hikaru, Yamagami, Akari, Hagiya, Kazutake, Minami, Tsuyoshi
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 21.09.2021
• Subjects: Aqueous solutions; Chemical sensors; Coordination compounds; Copper compounds; Discriminant analysis; Ethylenediamine; Histamine; Pattern recognition; Polyamines; Semiconductor devices; Sensors; Support vector machines; Thiadiazoles; Thin film transistors; Transistors; Tryptamines
• ISSN: 2050-7526; 2050-7534
• DOI: 10.1039/d1tc01542g

We herein report an extended gate-type organic thin-film transistor (OTFT)-based polyamine sensor and its application in pattern recognition. The extended-gate electrode was functionalized with a complex of copper( ii ) ions and 2-carboxymethylthio-5-mercapto-1,3,4-thiadiazole, which enabled the OTFT to respond to polyamines in an aqueous solution. Moreover, the responses of the OTFT-based sensor exhibited a cross-reactivity, implying its capability to detect multi-analytes. Thus, we performed pattern recognition against nine target polyamines (spermine, spermidine, trimethylenediamine, ethylenediamine, histamine, tryptamine, putrescine, cadaverine and 1,6-diaminohexane) in combination with linear discriminant analysis and successfully discriminated the analytes. Moreover, we achieved the quantification of spermine in a diluted fruit juice by using a support vector machine with high accuracy. Overall, the demonstration using the OTFT-based chemical sensor with pattern recognition revealed its potential for sensing polyamines in real samples. An extended-gate-type organic transistor functionalized with a carboxylate attached 1,3,4-thiadiazole derivative (TMT) allowed multi-polyamine discrimination based on a competitive assay among the TMT-based monolayer, copper( ii ) ions, and polyamines.