Implantable neural electrodes: from preparation optimization to application

Implantable neural electrodes are important tools for interfacing with the neural system for recording and stimulation. The structural and mechanical mismatch between traditional rigid electrodes and nerve tissue can lead to an inflammatory response and signal degradation during long-term implantati...

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Bibliographic Details
Published inJournal of materials chemistry. C, Materials for optical and electronic devices Vol. 11; no. 2; pp. 655 - 6572
Main Authors Zhang, Beilin, Xie, Ruijie, Jiang, Jiamin, Hao, Shiping, Fang, Bin, Zhang, Jiaxin, Bai, Hua, Peng, Bo, Li, Lin, Liu, Zhiyuan, Fu, Li
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 25.05.2023
Subjects
Electrodes
Implantation
Inflammatory response
Nerves
Optimization
Stretchability
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Summary:Implantable neural electrodes are important tools for interfacing with the neural system for recording and stimulation. The structural and mechanical mismatch between traditional rigid electrodes and nerve tissue can lead to an inflammatory response and signal degradation during long-term implantation. In recent years, researchers have continued to improve and innovate the material, structure, and implantation methods of electrodes to prepare flexible neural electrodes with better neural compatibility. In this review, the research progress on implantable neural electrodes is summarized from five aspects, namely materials, structures, stretchability, multifunctionality of flexible electrodes, and the application of implantable neural electrodes in nerve interfaces. Finally, the prospects for the implantable neural electrodes are discussed. Implantable neural electrodes are important tools for interfacing with the neural system for recording and stimulation.
Bibliography:Ruijie Xie is currently an Assistant Professor at the Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University. He received his BS from Shanxi Agriculture University and his PhD from the Institute of Advanced Materials, Nanjing Tech University. His research focuses on minimally invasive implantable sensors and leather-based flexible sensors.
Jiamin Jiang received her Bachelor's Degree from Xiangtan University (China) in June 2019, and then pursued her Master's Degree at Northwestern Polytechnical University (China). Her main research interests are exploration of biological applications of organic fluorescent materials.
Zhiyuan Liu is currently a professor at Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China. He received his BS from Harbin Institute of Technology and was awarded his PhD in Materials Science and Engineering (MSE) in 2017 from Nanyang Technological University (NTU), Singapore. During that time, he worked with Prof. Xiaodong Chen in Singapore and Prof. Zhenan Bao in Stanford University. His research interests are related to soft and stretchable bio-interface sensors.
Hua Bai received her PhD in Toxicology from the Fourth Military Medical University in 2011. In 2019, she obtained her current assistant professor position in Northwestern Polytechnical University (China). She has a long experience of studying redox biological signaling in human diseases, with a special focus on redox regulation in liver regeneration. Currently, her research interests involve mitochondrial dynamics and quality control in diseases associated with mitochondrial dysfunction.
Beilin Zhang received her MS in College of Chemistry and Materials Science from Northwest University in 2019. Currently, she is working as a PhD student at Northwestern Polytechnical University. Her research interests are mainly focused on implantable neural optoelectronic devices and photothermal therapy.
Li Fu received her BSc and PhD in Materials Science and Engineering from Northwestern Polytechnical University in 1993 and 2003, respectively. She has worked in Department of Microelectronics, Technical University of Hamburg (TUHH) in Germany for one year supported by China Scholarship Council. She obtained her current professor position in Northwestern Polytechnical University in 2006. Her research group focuses on the photoelectric functional materials and its devices.
ISSN:2050-7526
2050-7534
DOI:10.1039/d2tc05162a