Genetic heterogeneity of platelet glycoproteins Ia and IIIa and the risk of spontaneous miscarriages

The aim of this study was to investigate the association between the genetic heterogeneity of platelet glycoproteins Ia (GpIa-C807T) and IIIa (GpIIIa-PlA1/PlA2) and spontaneous abortions. Two hundred and twenty two women with a history of unexplained spontaneous miscarriages and no successful pregna...

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Published inThe journal of maternal-fetal & neonatal medicine Vol. 30; no. 11; p. 1309
Main Authors Vlachadis, Nikolaos, Tsamadias, Vasileios, Vrachnis, Nikolaos, Kaparos, Georgios, Vitoratos, Nikolaos, Kouskouni, Evaggelia, Economou, Emmanuel
Format Journal Article
LanguageEnglish
Published England 03.06.2017
Subjects
Abortion, Spontaneous - genetics
Adult
Alleles
Case-Control Studies
Female
Genetic Carrier Screening
Genetic Heterogeneity
Genotype
Humans
Integrin alpha2 - genetics
Integrin beta3 - genetics
Polymorphism, Single Nucleotide
Pregnancy
Risk Factors
Young Adult
GpIa
integrin alpha2
platelet glycoproteins
thrombophilia
GpIIIa
integrin beta3
Miscarriage
polymorphisms
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Summary:The aim of this study was to investigate the association between the genetic heterogeneity of platelet glycoproteins Ia (GpIa-C807T) and IIIa (GpIIIa-PlA1/PlA2) and spontaneous abortions. Two hundred and twenty two women with a history of unexplained spontaneous miscarriages and no successful pregnancy, and 60 fertile women serving as controls were genotyped for the GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms by pyrosequencing. In comparison with the common alleles homozygotes, GpIa-807T and GpIIIa-PlA2 carriers had an increased risk of fetal loss (OR = 3.36, 95%CI: 1.85-6.11, p < 0.001, and OR = 2.58, 95%CI: 1.30-5.13, p = 0.006, respectively). For subjects who were combined carriers of the GpIa-807T and GpIIIa-PlA2 alleles, the risk increased further (OR = 9.13, 95%CI: 2.99-27.82, p < 0.001). The above ORs were highest for women who were younger than 30 years of age. The GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms and more pronouncedly their combination are associated with increased risk of spontaneous abortions. The correlations were stronger for younger patients. Our results indicate that GpIa-807T and GpIIIa-PlA2 are susceptibility alleles for fetal loss in the Greek population.
ISSN:1476-4954
DOI:10.1080/14767058.2016.1212330