Recent developments on 1,2-difunctionalization and hydrofunctionalization of unactivated alkenes and alkynes involving C–S bond formation

Alkenes and alkynes are feedstock compounds and key units in many natural products, pharmaceuticals, agrochemicals, and organic functional materials. Hydrofunctionalization and 1,2-difunctionalization of alkenes and alkynes are of the most frequently used tools in organic synthesis for adding comple...

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Bibliographic Details
Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 10; no. 5; pp. 1322 - 1345
Main Authors Dong, Bo, Shen, Jian, Lan-Gui Xie
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 28.02.2023
Subjects
Agrochemicals
Alkenes
Alkynes
Carbon
Chemical bonds
Chemical synthesis
Covalent bonds
Functional materials
Natural products
Organic chemistry
Sulfur
Sulfur compounds
Transition metals
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Summary:Alkenes and alkynes are feedstock compounds and key units in many natural products, pharmaceuticals, agrochemicals, and organic functional materials. Hydrofunctionalization and 1,2-difunctionalization of alkenes and alkynes are of the most frequently used tools in organic synthesis for adding complexity to molecules. In this aspect, the construction of carbon–sulfur bonds through the functionalization of unactivated multiple carbon–carbon bonds represents a versatile way for the synthesis of sulfur-containing compounds. This review outlines recent progress on this topic, classified according to the activation of alkenes/alkynes following radical, electrophilic, and transition-metal catalyzed processes.
ISSN:2052-4110
2052-4110
DOI:10.1039/d2qo01699k