Leydig Cell Tumor-Induced Gonadotropin-Independent Precocious Puberty Progressing to Gonadotropin-Dependent Precocious Puberty Post Orchiectomy: Out of the Frying Pan Into the Fire

Many pathologies can cause gonadotropin-independent precocious puberty (GIPP) in prepubertal boys. Leydig cell tumor is one rare cause of this presentation. Here we present a six-year-old boy with features of isosexual precocious puberty, high testosterone levels, low gonadotropin levels, and bone a...

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Bibliographic Details
Published inCurēus (Palo Alto, CA) Vol. 14; no. 1; p. e21165
Main Authors Singhania, Pankaj, Bhattacharjee, Rana, Pratim Chakraborty, Partha, Chowdhury, Subhankar
Format Journal Article
LanguageEnglish
Published United States Cureus 12.01.2022
Subjects
Endocrinology/Diabetes/Metabolism
Oncology
Pediatrics
precocious
testosterone
ultrasonography
leydig cell tumor
puberty
testis
gnrh
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Summary:Many pathologies can cause gonadotropin-independent precocious puberty (GIPP) in prepubertal boys. Leydig cell tumor is one rare cause of this presentation. Here we present a six-year-old boy with features of isosexual precocious puberty, high testosterone levels, low gonadotropin levels, and bone age advancement. Testicular USG revealed a left-sided testicular tumor. The left testis was removed surgically, and the Leydig cell tumor was confirmed on histopathology. Post orchiectomy, the boy had elevated testosterone levels with raised luteinizing hormone (LH) levels. A diagnosis of gonadotropin-dependent precocious puberty (GDPP) was made. He has been initiated on monthly gonadotropin-releasing hormone (GnRH) agonist therapy.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.21165