Enantioselective total syntheses of (-)-cephalotaxine and (-)-amathaspiramide F through a key Ir/Cu dual catalysis

A recently developed Ir/Cu dual catalysed allylation, which could efficiently provide excellent enantio- and diastereoselectivity in the construction of vicinal tertiary and N-substituted quaternary stereogenic centres in one step, is strategically utilised for the first time in the syntheses of two...

Full description

Saved in:
Bibliographic Details
Published inORGANIC CHEMISTRY FRONTIERS Vol. 10; no. 10; pp. 2532 - 2537
Main Authors Sheng, Peng-Zhen, Li, Lu-Lu, Zhang, Hongbin, Wei, Kun, Yang, Yu-Rong
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 16.05.2023
Royal Society of Chemistry
Subjects
Allyl compounds
Catalysis
Chemical reactions
Chemistry
Chemistry, Organic
Enantiomers
Organic chemistry
Physical Sciences
Science & Technology
Stereoselectivity
(+/-)-CEPHALOTAXINE
REARRANGEMENT
ANNULATION
ALKYLATION
CONSTRUCTION
FORMAL TOTAL-SYNTHESIS
ALPHA-AMINO-ACIDS
CEPHALOTAXUS ALKALOIDS
AMATHASPIRAMIDES
CYCLIZATION
Online AccessGet full text

Cover

More Information
Summary:A recently developed Ir/Cu dual catalysed allylation, which could efficiently provide excellent enantio- and diastereoselectivity in the construction of vicinal tertiary and N-substituted quaternary stereogenic centres in one step, is strategically utilised for the first time in the syntheses of two alkaloids-cephalotaxine and amathaspiramide F.
ISSN:2052-4129
2052-4110
2052-4110
DOI:10.1039/d3qo00233k