Performances of ionic liquid matrices with butyl ammonium counterion for matrix-assisted laser desorption/ionization mass spectrometric detection and analysis of sucralfate

• Published in: Journal of carbohydrate chemistry Vol. 39; no. 1; pp. 1 - 23
• Main Authors: Petković, Marijana, Leopold, Jenny, Popović, Iva, Dimić, Dušan, Ilić, Jelica, Nenadović, Miloš, Rakočević, Zlatko, Schiller, Jürgen
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 02.01.2020; Taylor & Francis Ltd
• Subjects: 2,5-dihydroxybenzoic acid; 60 APPLIED LIFE SCIENCES; DESORPTION; DETECTION; Dihydroxybenzoic acid; Hydroxycinnamic acid; INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; Ionic liquid matrices; Ionic liquids; IONIZATION; Ions; LASERS; Mass spectrometry; MASS SPECTROSCOPY; MATRICES; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; MOLECULAR IONS; MOLTEN SALTS; Oligosaccharides; OPTICAL PROPERTIES; Sensitivity enhancement; sucralfate; α-cyano-hydroxycinnamic acid
• ISSN: 0732-8303; 1532-2327
• DOI: 10.1080/07328303.2019.1669633

In this work, the performances of two ionic liquid matrices (ILMs) with the same ammonium counterpart for mass spectrometric analysis of the insoluble and soluble sucralfate were compared. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) was performed assisted by the butylammonium salts of α-cyano-hydroxycinnamic acid (CHCAB) and 2,5-dihydroxybenzoic acid (DHBB). CHCAB has a higher IE than DHBB, but better optical properties. CHCAB is more suitable for the analysis of sucralfate, although molecular ions of both compounds were detectable only with low intensities. Thus, optical properties of ILMs are crucial to enhance the sensitivity of MALDI MS detection of polysulfated oligosaccharides.