Selective inactivation of hemagglutinin and neuraminidase on mumps virus

The thermal stability and the effect of guanidine on the hemagglutinin and neuraminidase of three strains of mumps virus were compared. The heat inactivation of hemagglutinin resulted in the concomitant loss of neuraminidase. The effect of guanidine at various molarities showed that the neuraminidas...

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Bibliographic Details
Published inArchives of virology Vol. 61; no. 4; p. 273
Main Authors Leprat, R, Aymard, M
Format Journal Article
LanguageEnglish
Published Austria 01.01.1979
Subjects
Allantois
Antigens, Viral
Blood
Guanidines - pharmacology
Hemagglutinins, Viral - immunology
Hot Temperature
Mumps virus - analysis
Mumps virus - immunology
Neuraminidase - immunology
Neuraminidase - metabolism
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Summary:The thermal stability and the effect of guanidine on the hemagglutinin and neuraminidase of three strains of mumps virus were compared. The heat inactivation of hemagglutinin resulted in the concomitant loss of neuraminidase. The effect of guanidine at various molarities showed that the neuraminidase was more sensitive than the hemagglutinin and a selective inactivation was obtained after exposure to 1.5 M guanidine. However differences in sensitivity of both activities (hemagglutinin and neuraminidase) to heat and guanidine inactivations were observed among strains and correlated with differential susceptibility to non-specific inhibitors of the strains.
ISSN:0304-8608
DOI:10.1007/BF01315013