Recent advances in catalytic enantioselective direct C–H bond functionalization of electron-deficient N-containing heteroarenes

Catalytic enantioselective direct C–H bond functionalization of electron-deficient N-containing heteroarenes represents one of the most straightforward and powerful protocols to construct diverse enantioenriched highly functionalized N-heteroarene products. Efficient catalytic systems and a variety...

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Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 9; no. 1; pp. 265 - 280
Main Authors Xiao-Lan, Liu, Luo-Bin, Jiang, Mu-Peng, Luo, Ren, Zhi, Shou-Guo, Wang
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 21.12.2021
Subjects
Electrons
Enantiomers
Hydrogen bonds
Organic chemistry
Stereoselectivity
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Summary:Catalytic enantioselective direct C–H bond functionalization of electron-deficient N-containing heteroarenes represents one of the most straightforward and powerful protocols to construct diverse enantioenriched highly functionalized N-heteroarene products. Efficient catalytic systems and a variety of strategies for highly chemo- and stereoselective C–H functionalization of electron-deficient N-containing heteroarenes have been developed over the past few decades. This review summarized the rapid progress in the catalytic asymmetric C–H functionalization of N-containing heteroarenes and discussed the challenges and potential of the field in the current stage.
ISSN:2052-4110
2052-4110
DOI:10.1039/d1qo01223a