Sex difference and the influence of endotoxin and hypertransfusion in spleen colony formation

Lethally whole-body irradiated mice upon receiving a relatively small quanity of marrow cells show a distinct sex difference in ability to support colony formation in spleen and cell proliferation in femoral marrow. The difference should be defined with reference to the organ in question. Female mic...

Full description

Saved in:
Bibliographic Details
Published inBlut Vol. 32; no. 5; p. 361
Main Authors Stevenson, A F, Duplan, J F
Format Journal Article
LanguageEnglish
Published Germany 01.05.1976
Subjects
Animals
Blood Transfusion
Bone Marrow Cells
Bone Marrow Transplantation
Endotoxins - pharmacology
Female
Hematopoiesis - drug effects
Male
Mice
Mice, Inbred Strains
Sex Factors
Spleen
Online AccessGet more information

Cover

More Information
Summary:Lethally whole-body irradiated mice upon receiving a relatively small quanity of marrow cells show a distinct sex difference in ability to support colony formation in spleen and cell proliferation in femoral marrow. The difference should be defined with reference to the organ in question. Female mice manifest more efficient splenic haematopoiesis while among the males myeloid haematopoiesis, as measured by 59Fe and 125IUdR incorporation, seems to be greater. Endotoxin treatment and hypertransfusion exert profound influences, interacting with the sex-hormonal status of the animal.
ISSN:0006-5242
DOI:10.1007/BF00996476