Carboxylic acid-assisted sterically demanding reductive cross-coupling between cycloalkenyl and alkyl bromides

A nickel-catalysed reductive cross-coupling reaction between 2-bromo cycloalkenyl carboxylic acids and alkyl bromides has been developed, affording all-carbon tetrasubstituted cycloalkenes in moderate to excellent yields up to 92%. Mechanistic studies indicated that the carboxylic acid group plays a...

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Published inORGANIC CHEMISTRY FRONTIERS Vol. 10; no. 8; pp. 1897 - 1902
Main Authors An, Jinglin, Zhou, Xue, Zhang, Yifan, Ye, Zhenfei, Guo, Qianyou, Song, Hao, Song, Zhenlei, Liu, Xiao-Yu, Qin, Yong
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 11.04.2023
Royal Society of Chemistry
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Summary:A nickel-catalysed reductive cross-coupling reaction between 2-bromo cycloalkenyl carboxylic acids and alkyl bromides has been developed, affording all-carbon tetrasubstituted cycloalkenes in moderate to excellent yields up to 92%. Mechanistic studies indicated that the carboxylic acid group plays an important assisting role in this sterically demanding coupling reaction.
ISSN:2052-4129
2052-4110
2052-4110
DOI:10.1039/d3qo00155e