Cocrystal formation by anti-solvent slurry

An anti-solvent slurry method for cocrystal formation is developed and tested in 25 carbamazepine cocrystal systems. With a low solvent/anti-solvent volume ratio, it reduces solubility of reactants and products, and levels out solubility difference of reactants, and consequently generates cocrystals...

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Bibliographic Details
Published inCrystEngComm Vol. 25; no. 42; pp. 5882 - 5886
Main Authors Li, Yi, Li, Shun-Yu, Dai, Xia-Lin, Lu, Tong-Bu, Chen, Jia-Mei
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 30.10.2023
Subjects
Slurries
Solubility
Solvents
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Summary:An anti-solvent slurry method for cocrystal formation is developed and tested in 25 carbamazepine cocrystal systems. With a low solvent/anti-solvent volume ratio, it reduces solubility of reactants and products, and levels out solubility difference of reactants, and consequently generates cocrystals with a higher success rate, higher purity and higher yield than commonly used slurry methods. An anti-solvent slurry method for cocrystal formation is developed and tested in 25 carbamazepine cocrystal systems, which reveals that it is a facile, efficient and reliable method for cocrystal discovery and synthesis.
Bibliography:1
https://doi.org/10.1039/d3ce00486d
Electronic supplementary information (ESI) available: Experimental details, PXRD patterns of each cocrystal system
H NMR spectra and TG-DSC curves of newly obtained forms. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1466-8033
1466-8033
DOI:10.1039/d3ce00486d