Rapid prototyping of microfluidic devices with a wax printer

We demonstrate a rapid and inexpensive approach for the fabrication of high resolution poly(dimethylsiloxane) (PDMS)-based microfluidic devices. The complete process of fabrication could be performed in several hours (or less) without any specialized equipment other than a consumer-grade wax printer...

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Bibliographic Details
Published inLab on a chip Vol. 7; no. 3; p. 384
Main Authors Kaigala, Govind V, Ho, Sunny, Penterman, Roel, Backhouse, Christopher J
Format Journal Article
LanguageEnglish
Published England 01.01.2007
Subjects
Humans
Immunohistochemistry
Mammary Glands, Human - cytology
Microfluidics - instrumentation
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Summary:We demonstrate a rapid and inexpensive approach for the fabrication of high resolution poly(dimethylsiloxane) (PDMS)-based microfluidic devices. The complete process of fabrication could be performed in several hours (or less) without any specialized equipment other than a consumer-grade wax printer. The channels produced by this method are of high enough quality that we are able to demonstrate the sizing and separation of DNA fragments using capillary electrophoresis (CE) with no apparent loss of resolution over that found with glass chips fabricated by conventional photolithographic methods. We believe that this method will greatly improve the accessibility of rapid prototyping methods.
ISSN:1473-0197
DOI:10.1039/b617764f