Synthesis of Au/lignin-tannin particles and their anticancer application

Gold (Au) nanoparticles are widely adopted as nonbiological-toxic and biocompatible biomaterials. In this study, Au nanoparticles supported on lignin-tannin (LT) micro-/nanoparticles were prepared via a green and novel method without the use of an additional reducing agent. Soluble lignin oligomers...

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Published inGreen chemistry : an international journal and green chemistry resource : GC Vol. 23; no. 18; pp. 6945 - 6952
Main Authors Jiang, Zhicheng, Duan, Jinjie, Guo, Xingjie, Ma, Ya, Wang, Chunjiong, Shi, Bi
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 21.09.2021
Subjects
Bark
Biocompatibility
Biomaterials
Biomedical materials
Forest biomass
Forestry wastes
Gold
Green chemistry
Lignin
Nanoparticles
Oligomers
Phenolic compounds
Phenols
Reagents
Reducing agents
Self-assembly
Tannins
Tetrahydrofuran
Thermal stability
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Summary:Gold (Au) nanoparticles are widely adopted as nonbiological-toxic and biocompatible biomaterials. In this study, Au nanoparticles supported on lignin-tannin (LT) micro-/nanoparticles were prepared via a green and novel method without the use of an additional reducing agent. Soluble lignin oligomers and tannin were first obtained from H 2 O-tetrahydrofuran (THF) solvothermal treatment of the corncob residue and bayberry bark, which are industrial and forestry wastes of biomass, respectively. With outstanding self-assembly capability, the lignin oligomers induced the co-self-assembly of tannins into LT particles considerably, which enhanced the density of ortho -phenolic hydroxyls on the hydrophilic shell. Consequently, Au 3+ can be stabilized and subsequently reduced into Au 0 particles that were highly dispersed on the LT particles. Upon increasing the proportion of tannins, the amount of Au species on LT particles and the Au 0 /Au n + ratio increased, accompanied by the inferior thermal stability of the particles. In addition, the as-prepared Au/LT particles can be taken up by cells and can reduce the vitality of several cancer cells, indicating a potential biotherapy application. Au 3+ ions could be reduced to Au 0 particles and stabilized on lignin-tannin particles without the use of reducing agents and surfactants.
Bibliography:10.1039/d1gc01119g
Electronic supplementary information (ESI) available. See DOI
ISSN:1463-9262
1463-9270
DOI:10.1039/d1gc01119g