Enhanced neuronal differentiation using plasma synthesized amino polymers

Different pyrrole and allylamine polymeric materials, were synthesized by plasma polymerization with different powers and doped with iodine. The polymers were characterized physicochemically. A cell line of neuronal origin (N1E-115) was cultured on them to evaluate the effects of the materials on ne...

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Bibliographic Details
Published inInternational journal of polymeric materials Vol. 74; no. 1; pp. 11 - 20
Main Authors Alvarado Muñoz, Estephanny Jocelyn, Olayo González, Roberto, Olayo González, María Guadalupe, Cruz Cruz, Guillermo Jesús, Uribe Juárez, Omar Eduardo, Coyoy Salgado, Angélica, Martinez Fong, Daniel, Salgado Ceballos, Hermelinda, Orozco Barrios, Carlos Enrique, Morales Corona, Juan
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis Ltd 02.01.2025
Subjects
Chemical synthesis
Differentiation
Immunofluorescence
Iodine
Polymers
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Summary:Different pyrrole and allylamine polymeric materials, were synthesized by plasma polymerization with different powers and doped with iodine. The polymers were characterized physicochemically. A cell line of neuronal origin (N1E-115) was cultured on them to evaluate the effects of the materials on neuronal differentiation. Following a differentiation stimulus, immunofluorescence was performed, and the lengths of neurites, as well as the complexity of the network formed and the number of nuclei, were measured and analyzed to provide a differentiation index. The results showed that the polymeric materials exhibited different physicochemical characteristics depending on the synthesis conditions and enhanced neuronal differentiation.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2024.2312824