Tissue Microarray for Routine Clinical Breast Biomarker Analysis: The British Columbia Cancer Agency 2008 Experience

• Published in: American journal of clinical pathology Vol. 133; no. 6; pp. 909 - 914
• Main Authors: THOMSON, Thomas A, CHEN ZHOU, CEBALLOS, Kathy, KNIGHT, Bryan
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Society of Clinical Pathologists 01.06.2010
• Subjects: Biological and medical sciences; Biomarkers, Tumor - analysis; Breast - chemistry; Breast Neoplasms - chemistry; British Columbia; Chromosomes, Human, Pair 17 - chemistry; Gynecology. Andrology. Obstetrics; Humans; Investigative techniques, diagnostic techniques (general aspects); Mammary gland diseases; Medical sciences; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Receptor, ErbB-2 - analysis; Receptors, Estrogen - analysis; Tissue Array Analysis - economics; Tumors; Canada; British Columbia; North America; America; Estrogen receptor; Breast disease; Estrogen; erbB2 Gene; Biological marker; Progesterone receptor; Tissue microarrays; Mammary gland; Protooncogene; Routine analysis; Biological indicator; Tissue microarray; Breast cancer; Malignant tumor; Ovarian hormone; Human Epidermal growth factor Receptor 2; Mammary gland diseases; Anatomic pathology; C-Onc gene; Breast; Biomarkers; Sex steroid hormone; HER2; Cancer; Hormonal receptor
• ISSN: 0002-9173; 1943-7722
• DOI: 10.1309/AJCP1IU7BTSAQGYZ

Clinical use of tissue microarrays for immunohistochemical analysis of breast biomarkers, namely estrogen receptor, progesterone receptor, and HER2, was instituted in our laboratory in 2008. The method has proved reliable and cost-effective. We report the results of the initial year of testing with this method.