Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids

• Published in: ORGANIC CHEMISTRY FRONTIERS Vol. 8; no. 23; pp. 6603 - 6608
• Main Authors: Jiao, Ke-Jin, Ma, Cong, Liu, Dong, Qiu, Hui, Cheng, Bin, Mei, Tian-Sheng
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 23.11.2021; Royal Society of Chemistry
• Subjects: Acylation; Bromides; Carboxylic acids; Chemistry; Chemistry, Organic; Cross coupling; Electrochemistry; Functional groups; Halides; Ketones; Nickel; Organic chemistry; Physical Sciences; Relay; Science & Technology; FUNCTIONALIZATION; MILD; KETONE SYNTHESIS; ESTERS; CHLORIDES; ARYL; REMOTE; BROMIDES; ELECTROPHILES; HYDROARYLATION

A highly regioselective Ni-catalyzed electrochemical (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides has been developed. This strategy allows the direct acylation of benzylic C(sp(3))-H bonds in good yields from commercially available alkyl carboxyli...