Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids
A highly regioselective Ni-catalyzed electrochemical (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides has been developed. This strategy allows the direct acylation of benzylic C(sp(3))-H bonds in good yields from commercially available alkyl carboxyli...
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Published in | ORGANIC CHEMISTRY FRONTIERS Vol. 8; no. 23; pp. 6603 - 6608 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
23.11.2021
Royal Society of Chemistry |
Subjects | |
Online Access | Get full text |
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Summary: | A highly regioselective Ni-catalyzed electrochemical (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides has been developed. This strategy allows the direct acylation of benzylic C(sp(3))-H bonds in good yields from commercially available alkyl carboxylic acids, thus providing an alternative strategy for the synthesis of dialkyl ketones. Various functional groups are tolerated under mild reaction conditions. |
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ISSN: | 2052-4129 2052-4110 2052-4110 |
DOI: | 10.1039/d1qo01219c |