Photoredox-catalysed hydroaminoalkylation of on-DNA N -arylamines

An efficient approach to the photoredox-catalysed hydroaminoalkylation between on-DNA secondary -substituted (hetero)arylamines and vinylarenes has been developed and explored. The methodology was examined with a broad scope of vinylarenes and secondary arylamines to establish a preferred building b...

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Published inOrganic & biomolecular chemistry Vol. 21; no. 7; pp. 1463 - 1467
Main Authors Mahdavi-Amiri, Yasaman, Hu, Molly S J, Frias, Nicole, Movahedi, Matina, Csakai, Adam, Marcaurelle, Lisa A, Hili, Ryan
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 15.02.2023
Subjects
Amines
Deoxyribonucleic acid
DNA
Organic compounds
Photoredox catalysis
Substrates
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Summary:An efficient approach to the photoredox-catalysed hydroaminoalkylation between on-DNA secondary -substituted (hetero)arylamines and vinylarenes has been developed and explored. The methodology was examined with a broad scope of vinylarenes and secondary arylamines to establish a preferred building block profile for the process. Compatible substrates furnished the desired derivitised amine products in modest to excellent conversions and with minimal or no detectable by-products.
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ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob01956f