Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application
As one of the major derivatives of biguanides, poly(hexamethylene biguanide) hydrochloride (PHMB) is a well-known commercially available polycationic antiseptic and disinfectant. PHMB is the hydrochloride salt of an amino polymer composed of an average of 12-16 biguanide groups separated by hydropho...
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| Published in | Polymer chemistry Vol. 14; no. 48; pp. 5226 - 5252 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge
Royal Society of Chemistry
12.12.2023
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| Subjects | |
| Online Access | Get full text |
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| Summary: | As one of the major derivatives of biguanides, poly(hexamethylene biguanide) hydrochloride (PHMB) is a well-known commercially available polycationic antiseptic and disinfectant. PHMB is the hydrochloride salt of an amino polymer composed of an average of 12-16 biguanide groups separated by hydrophobic hexamethylene segments in the main chain. As a result, PHMB combines the advantageous characteristics of the biguanide group and polymeric polyelectrolyte. Currently, PHMB is regarded as a versatile biguanide-containing cationic polyelectrolyte, thus having a wide range of application prospects such as photoelectrical devices, gene delivery, clean coloration, CO
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capture, and uranium recovery, as well as the well-accepted antimicrobial behavior. More interestingly, PHMB exhibits a remarkable ability to overcome charge screening limitations caused by inorganic salts when used for flocculating wastewater. Even though PHMB has been extensively reviewed in terms of its antimicrobial/antiviral activity and clinical applications over the past few decades, a comprehensive review on the synthesis, modification strategies, quantitative determination, and applications of PHMB in recent years is still lacking. Herein, we for the first time present a timely review to give a panoramic view of PHMB covering these aspects. The review article presented here may shed light on a more rational exploration of PHMB-based materials for various applications.
Conceptual diagram of the current review covering the synthesis, modification, properties, determination, and applications of PHMB-based materials. |
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| Bibliography: | Huawen Hu received his Ph.D. degree from the Hong Kong Polytechnic University in 2015 and joined Foshan University as a distinguished professor in 2016. Prof. Hu was elected to the Guangdong Topnotch Young Talents Program of Pearl River Recruitment Program of Talents and rewarded with Best Papers of 2022 from RSC's Environmental Science journals. He was named in the world's top 2% of Scientists List in 2022 and 2023. He has over 90 peer-reviewed publications in top journals, with an h-index of 35. His research interests mainly include carbon-based functional materials for energy, catalysis, and environmental remediation applications. Dr Chi-Wai Kan is a Professor in the School of Fashion and Textiles, The Hong Kong Polytechnic University. He graduated from The Hong Kong Polytechnic University with a B.Sc. and Ph.D. in Textile Chemistry. He had worked in the private and public sectors in the area of textile evaluation and safety and health management for more than 5 years before joining the School. His main duties in the School are in the area of teaching coloration and finishing of textiles, and his research interests are also in the area of coloration and finishing. Dr Wenyi Wang received his Ph.D. degree from the Hong Kong Polytechnic University in 2017. After spending several years as a research associate and postdoctoral fellow in Prof. Chi-wai Kan's group, he embarked on his new research career serving as a Research Assistant Professor in 2022. Currently, Dr Wang's research areas cover transdermal drug delivery systems, polymeric biomaterials, sustainable eco-friendly coloration technology, novel polymeric materials for specific applications etc modulation of the gut microbiome. She has also worked on the development of antimicrobial and antiviral materials Dr Amber Chiou Jiachi received her Ph.D. from the Department of Food Science, with the discipline Molecular Biology and Microbiology, Rutgers University, USA. During the postdoctoral period, she participated in research projects on the multi-drug resistance of food-borne pathogens, and development of new antibiotics. As a Principal Investigator since 2016, Dr Chiou has started projects related to how dietary factors affect human health collaboration with chemists. Her research team includes members with multidisciplinary expertise such as microbiology, metabolomics, nutrition, and bioinformatics. . via |
| ISSN: | 1759-9954 1759-9962 |
| DOI: | 10.1039/d3py01148h |