Variability of prolactin response to intravenous and intramuscular haloperidol in normal adult men

Serum prolactin (PRL) concentrations were monitored in seven normal adult men for 1 h before and 7 h after i.v. and i.m. injection of 0.25 mg and 0.50 mg haloperidol. The magnitude of the PRL response was dose-related but quite variable across subjects. The patterns of PRL secretion over the 7 h pos...

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Bibliographic Details
Published inPsychopharmacology Vol. 61; no. 1; p. 17
Main Authors Rubin, R T, Hays, S E
Format Journal Article
LanguageEnglish
Published Germany 01.01.1979
Subjects
Adult
Haloperidol - administration & dosage
Haloperidol - blood
Haloperidol - pharmacology
Humans
Injections, Intramuscular
Injections, Intravenous
Male
Prolactin - blood
Time Factors
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Summary:Serum prolactin (PRL) concentrations were monitored in seven normal adult men for 1 h before and 7 h after i.v. and i.m. injection of 0.25 mg and 0.50 mg haloperidol. The magnitude of the PRL response was dose-related but quite variable across subjects. The patterns of PRL secretion over the 7 h post-injection period also varied greatly among the subjects. Differences in serum heloperidol concentrations accounted for 88% of the variability in the magnitude of the PRL response to the 0.5 mg IM haloperidol dose, but only accounted for 60% of the PRL variability following the 0.5 mg IV dose. The pattern of haloperidol disappearance from serum was similar across the seven subjects and thus unrelated to the variable patterns of PRL response.
ISSN:0033-3158
DOI:10.1007/BF00426804