Water-soluble poly( n -vinylamides)as a basis for the synthesis of polymeric carriers of biologically active compounds

The method for preparation of copolymers of N-vinylpyrrolidone (VP) and N-vinylamine (VA) with high yield were developed; the method involves radical copolymerization of VP with N-vinylformamide(VFA) followed by the removal of formyl protecting group in the presence of inorganic acids. The optimal c...

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Bibliographic Details
Published inInternational journal of polymer analysis & characterization Vol. 24; no. 2; pp. 105 - 113
Main Authors Santuryan, Yu G., Malakhova, I. I., Gorshkov, N. I., Krasikov, V. D., Panarin, E. F.
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis Ltd 17.02.2019
Subjects
Chemical synthesis
Chromatography
Control methods
Copolymerization
Copolymers
Formic acid
Inorganic acids
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Summary:The method for preparation of copolymers of N-vinylpyrrolidone (VP) and N-vinylamine (VA) with high yield were developed; the method involves radical copolymerization of VP with N-vinylformamide(VFA) followed by the removal of formyl protecting group in the presence of inorganic acids. The optimal conditions for synthesis of copolymers with predefined compositions and molecular masses were determined. The influence of temperature, concentrations of reactants, and the nature of an acid on the rate of formyl group removal was estimated. Spectral and chromatographic methods of analytical control of the contents of residual monomers and formic acid (which forms during acidic hydrolysis of the copolymer) were developed.
ISSN:1023-666X
1563-5341
DOI:10.1080/1023666X.2018.1551270