Chemistry of 3-hydroxy-2-aryl acrylate: syntheses, mechanisms, and applications

The discovery of the 3-hydroxy-2-aryl acrylate was a significant breakthrough in the field of organic and medicinal chemistry. Due to the presence of both electrophilic and nucleophilic centers, this scaffold acts as a fascinating building block of many bioactive compounds. More importantly, 3-hydro...

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Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 8; no. 1; pp. 169 - 191
Main Authors Rahaman, Mizzanoor, Ali, M Shahnawaz, Jahan, Khorshada, Jawad Bin Belayet, A F M Towheedur Rahman, Hossain, M Mahmun
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 07.01.2021
Subjects
Aromatic compounds
Bioactive compounds
Drug development
Natural products
Organic chemistry
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Summary:The discovery of the 3-hydroxy-2-aryl acrylate was a significant breakthrough in the field of organic and medicinal chemistry. Due to the presence of both electrophilic and nucleophilic centers, this scaffold acts as a fascinating building block of many bioactive compounds. More importantly, 3-hydroxy-2-aryl acrylate is a vital precursor in the synthesis of natural products and in the development of essential drugs. In this first review, we outline different approaches for preparing 3-hydroxy-2-aryl acrylate with mechanisms and its application in a variety of chemical fields.
ISSN:2052-4110
2052-4110
DOI:10.1039/d0qo01157f