ATTITUDE OF INTERSTITIAL TISSUE OF THE VESICAL WALL IN THE CANCER OF URINARY BLADDER

• Published in: Nippon Hinyokika Gakkai zasshi Vol. 56; no. 3; pp. 289 - 296
• Main Authors: Suzuki, Ki-ichi, Natsume, Osamu, Sugita, Atsuo, Kato, Masakazu, Anno, Ei-ichi, Kato, Teruhiko
• Format: Journal Article
• Language: English; Japanese
• Published: Japan THE JAPANESE UROLOGICAL ASSOCIATION 1965
• Subjects: Humans; In Vitro Techniques; Urinary Bladder Neoplasms - pathology
• ISSN: 0021-5287; 1884-7110
• DOI: 10.5980/jpnjurol1928.56.3_289

The attitude of interstitial tissue of the vesical wall was observed histologically on the whole layer specimen of bladder carcinoma in 55 cases. The results obtained were as follows: These bladder carcinoma were classified with its cell type as into 49 of transitional carcinoma and 6 of undifferentiated ones. According to Broder's classification with malignancy grading, it was found that these were composed of 3 of 1st grade, 15 of 2nd grade, 21 of 3rd grade, and 10 of 4th grade of transitional type, and 2 of 3rd grade and 4 of 4th grade of undifferentiated type, respectively. Therefore, there could be found mainly of 2nd, 3rd, and 4th grade of the formers and 4th grade of the latters. The cell infiltration and the subsequently developed granulatin were found in the interstitial tissue of the less malignant transitional carcinoma, as 3 in 3 of 1st grade and 14 in 15 of 2nd grade, while in the much malignant one, there could be found the fibrosis of he interstital tissue, as 10 in 21 of 3rd grade and 7 in 10 of 4th grade. And furthermore, the fibrosis of the interstitial tissue was found in all cases of 3rd and 4th grade of undifferentiated carcinoma. These results were thought to reveal the fact that the cell infiltration or the granulation in the interstitial tissue could be found mainly in the less malignant carcinoma, while the fibrosis, the increase in number of interstitial cells, could be found corresponding to the development of the malignancy of the tumor. The almost same results were obtained with the observation on the interstitial tissue of vesical wall around the tumor. In the bladder carcinoma, there should be found certain inflammatory cell infiltration in the submucosal layer of the vesical wall just same as seen in the simple cystitis. The cell infiltration and the subsequent granulation or fibrosis was found in all cases in the interstitial tissue of the tumor or the vesical wall around the tumor. In these cell infiltration, the lymph cells, the polynuclear leucocytes, and the basophilic leucocytes were significantly observed, while the figure of the granulation or the fibrosis in various grade was found in different part of the same specimen. And these changes around the tumor were observed markedly just like enveloping the tumor tissue, however, the cell infiltration in the distant part from the tumor was rather slight. These results were tought to reveal the fact that the interstitial tissue of the vesical wall with the bladder carcinoma would show certain protective reaction just like the other interstitial tissue with some malignant tumor.