Peutz–Jeghers syndrome complicated by gastric‐type cervical mucinous carcinoma and primary peritoneal carcinoma

A 45‐year‐old multiparous woman with a STK11 mutation and a history of Peutz–Jeghers syndrome underwent radical hysterectomy and bilateral salpingo‐oophorectomy for a gastric‐type cervical mucinous carcinoma. Four and a half years later, blood tests revealed elevations in CEA and CA125 tumor marker...

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Published inThe journal of obstetrics and gynaecology research Vol. 47; no. 10; pp. 3732 - 3736
Main Authors Kotaka, Saki, Kanno, Kiyoshi, Yanai, Shiori, Omori, Masako, Andou, Masaaki
Format Journal Article
LanguageEnglish
Published Kyoto, Japan John Wiley & Sons Australia, Ltd 01.10.2021
Wiley Subscription Services, Inc
Subjects
Bevacizumab
Biopsy
BRCA1 protein
Cancer
Carboplatin
Cervix
Chemotherapy
Computed tomography
Gastric cancer
gastric type
high‐grade serous carcinoma
Hysterectomy
Laparoscopy
mucinous carcinoma
Mutation
Ovariectomy
Peritoneum
Peutz–Jeghers syndrome
primary peritoneal carcinoma
Remission
Tumor markers
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Summary:A 45‐year‐old multiparous woman with a STK11 mutation and a history of Peutz–Jeghers syndrome underwent radical hysterectomy and bilateral salpingo‐oophorectomy for a gastric‐type cervical mucinous carcinoma. Four and a half years later, blood tests revealed elevations in CEA and CA125 tumor marker levels, and computed tomography showed multiple calcifications in the peritoneum. Peritoneal dissemination was suspected, and a laparoscopic biopsy was performed. Histopathology showed a high‐grade serous carcinoma, and the patient was diagnosed with a metachronous stage IIIC primary peritoneal carcinoma. She had no BRCA1/2 mutation. After chemotherapy with docetaxel, carboplatin, and bevacizumab, she achieved complete remission.
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.14944