Pitfalls in Morphologic Diagnosis of Pathogens: Lessons Learned From the Pseudo- Cystoisospora Epidemic

Multiple groups have recently reported involvement of the gallbladder mucosa of immunocompetent patients by cystoisospora organisms. However, this has recently been disproved with the support of molecular and ultrastructural studies. Here we present a summary of these events, recounting how this pse...

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Published inInternational journal of surgical pathology Vol. 29; no. 2; p. 169
Main Authors Gopinath, Arun, Alkhasawneh, Ahmad, Mubeen, Aysha, Makary, Raafat, Mohammed, Ibraheem, Baskovich, Brett
Format Journal Article
LanguageEnglish
Published United States 01.04.2021
Subjects
inclusion
gallbladder
gastric
Cystoisospora
epithelial
molecular
ultrastructural
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Summary:Multiple groups have recently reported involvement of the gallbladder mucosa of immunocompetent patients by cystoisospora organisms. However, this has recently been disproved with the support of molecular and ultrastructural studies. Here we present a summary of these events, recounting how this pseudo-Cystoisospora epidemic began and ended. This review also highlights the important role played by ancillary techniques in supplementing the morphologic diagnosis of pathogens.
ISSN:1940-2465
DOI:10.1177/1066896920960813