Risk of T2DM and impaired fasting glucose among pcos subjects: Results of an 8-year follow-up

• Published in: Current diabetes reports Vol. 6; no. 1; pp. 77 - 83
• Main Authors: Boudreaux, Monique Y., Talbott, Evelyn O., Kip, Kevin E., Brooks, Maria M., Witchel, Selma F.
• Format: Journal Article
• Language: English
• Published: United States 01.02.2006
• Subjects: Adult; Blood Glucose - metabolism; Body Mass Index; Diabetes Mellitus, Type 2 - epidemiology; Fasting; Female; Follow-Up Studies; Humans; Hyperglycemia - epidemiology; Polycystic Ovary Syndrome - complications; Polycystic Ovary Syndrome - mortality; Reference Values; Risk Factors; Smoking; Survival Analysis
• ISSN: 1534-4827; 1539-0829
• DOI: 10.1007/s11892-006-0056-1

Women with polycystic ovary syndrome (PCOS) often develop type 2 diabetes mellitus (T2DM). To determine the magnitude of risk of developing T2DM among women with PCOS, development of T2DM was prospectively assessed among women who had T2DM (n = 97) and controls (n = 95) using Kaplan-Meier survival analysis and Cox proportional hazards modeling. The women with T2DM had higher baseline weight (body mass index, P < 0.01) and lower insulin sensitivity (homeostasis assessment model of insulin resistance, P < 0.01). The 8-year incidence rate among cases and controls was 13.4% and 5.8%, respectively (relative risk = 2.3). Obese cases had a fivefold risk of T2DM developing (P < 0.01) compared with age-adjusted obese controls, indicating significant interaction between PCOS and obesity to effect T2DM risk.