Anticholinesterase mechanism as a factor of immunotoxicity of various chemical compounds

Experiments on Wistar rats showed that acute poisoning with chemicals in a dose of 0.75 LD(50) (dimethyl dichlorovinyl phosphate, sarin, VX substance, sulfur yperite, lewisite, tetraethyl lead, dichloroethane) inhibiting platelet acetylcholine esterase, alpha-naphthyl-AS-acetate esterase, and alpha-...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 136; no. 2; p. 176
Main Authors Zabrodskii, P F, Germanchuk, V G, Kirichuk, V F, Nodel', M L, Aredakov, A N
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.08.2003
Subjects
Animals
Cholinesterase Inhibitors - immunology
Cholinesterase Inhibitors - metabolism
Cholinesterase Inhibitors - toxicity
Enzyme Inhibitors - metabolism
Esterases - antagonists & inhibitors
Esterases - metabolism
Immune System - physiology
Immunotoxins - metabolism
Male
Rats
Rats, Wistar
Spleen - cytology
T-Lymphocytes - enzymology
T-Lymphocytes - immunology
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Summary:Experiments on Wistar rats showed that acute poisoning with chemicals in a dose of 0.75 LD(50) (dimethyl dichlorovinyl phosphate, sarin, VX substance, sulfur yperite, lewisite, tetraethyl lead, dichloroethane) inhibiting platelet acetylcholine esterase, alpha-naphthyl-AS-acetate esterase, and alpha-naphthyl-butyrate esterase suppressed T cell-mediated immune reactions.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1026327225739