3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

A new analogue of fluorinated pyrazoline (compound 1) has been synthesized via one-pot three-component reaction in a sealed-vessel reactor, Monowave 50. The structure of compound 1 has been established by spectroscopy analysis, including UV, FT-IR, HRMS, 1H and 13C NMR spectroscopy. Based on the in...

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Bibliographic Details
Published inMolBank Vol. 2019; no. 4; p. M1088
Main Authors Zamri, Adel, Teruna, Hilwan Y., Wulansari, Sri, Herfindo, Noval, Frimayanti, Neni, Ikhtiarudin, Ihsan
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.12.2019
Subjects
Binding sites
Caustic soda
Dengue fever
Ethanol
Hydrogen bonds
Infrared analysis
Infrared spectroscopy
Ligands
NMR spectroscopy
Pyrazole
Simulation
Viruses
United States > US
Japan
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Summary:A new analogue of fluorinated pyrazoline (compound 1) has been synthesized via one-pot three-component reaction in a sealed-vessel reactor, Monowave 50. The structure of compound 1 has been established by spectroscopy analysis, including UV, FT-IR, HRMS, 1H and 13C NMR spectroscopy. Based on the in silico studies, this compound showed a good potential as an inhibitor for dengue virus type 2 (DEN2) NS2B/NS3 serine protease and can be used as a reference in the next design of an antidengue virus.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1088