The ring-opening reaction of 3,3,3-trifluoropropene oxide with carbanions: Reaction of alpha-cyanocarbanions

Nucleophilic ring-opening reaction of 3,3,3-trifluoropropene oxide (TFPO) was studied. Reaction of TFPO with carbanions stabilized by cyano group gave gamma-cyanohydrins in moderate to good yields. Meanwhile, reaction of the carbanions from malonic ester and nitromethane resulted in recovery of TFPO...

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Bibliographic Details
Published inChemistry letters no. 6; pp. 549 - 550
Main Authors Katagiri, T, Akizuki, M, Kuriyama, T, Shinke, S, Uneyama, K
Format Journal Article
LanguageEnglish
Published TOKYO Chemical Soc Japan 01.06.1997
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
ALCOHOLS
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Summary:Nucleophilic ring-opening reaction of 3,3,3-trifluoropropene oxide (TFPO) was studied. Reaction of TFPO with carbanions stabilized by cyano group gave gamma-cyanohydrins in moderate to good yields. Meanwhile, reaction of the carbanions from malonic ester and nitromethane resulted in recovery of TFPO.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.1997.549