Urinary ligandin and glutathione-S-transferase in gentamicin-induced nephrotoxicity in the rat

1. Eight rats developed detectable glutathione-S-transferase activity in their urine after three daily injections of toxic doses of gentamicin. 2. Seven of the eight rats had immunodetectable ligandin in their urine at this time. 3. The level of enzyme activity correlated well with the degree of ele...

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Bibliographic Details
Published inClinical science (1979) Vol. 61; no. 1; pp. 123 - 125
Main Authors Feinfeld, D A, Fleischner, G M, Arias, I M
Format Journal Article
LanguageEnglish
Published England 01.07.1981
Subjects
Animals
Creatinine - blood
Disease Models, Animal
Female
Gentamicins - toxicity
Glutathione Transferase - urine
Kidney Diseases - chemically induced
Kidney Diseases - enzymology
Kidney Tubules, Proximal - drug effects
Rats
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Summary:1. Eight rats developed detectable glutathione-S-transferase activity in their urine after three daily injections of toxic doses of gentamicin. 2. Seven of the eight rats had immunodetectable ligandin in their urine at this time. 3. The level of enzyme activity correlated well with the degree of elevation of serum creatinine. 4. This confirms ligandinuria and urinary glutathione-S-transferase as markers of acute renal proximal tubular injury.
ISSN:0143-5221
1470-8736
DOI:10.1042/cs0610123