p53 Genetics and Biology in Lung Carcinomas: Insights, Implications and Clinical Applications

The gene is renowned as a tumor suppressor, playing a pivotal role in overseeing the cell cycle, apoptosis, and maintaining genomic stability. Dysregulation of p53 often contributes to the initiation and progression of various cancers, including lung cancer (LC) subtypes. The review explores the int...

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Published inBiomedicines Vol. 12; no. 7; p. 1453
Main Authors Benitez, Dixan A, Cumplido-Laso, Guadalupe, Olivera-Gómez, Marcos, Del Valle-Del Pino, Nuria, Díaz-Pizarro, Alba, Mulero-Navarro, Sonia, Román-García, Angel, Carvajal-Gonzalez, Jose Maria
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 29.06.2024
Subjects
Apoptosis
Cancer therapies
Cell cycle
Cell growth
DNA damage
DNA repair
Genes
Genomes
Haplotypes
Homeostasis
Isoforms
Lung cancer
lung cancer subtypes
Lung carcinoma
lung squamous cell carcinoma
Medical prognosis
mutated p53
Mutation
p53
p53 Protein
Phosphatase
Polymorphism
Proteins
Retinoblastoma
Roles
Senescence
squamous cell carcinoma
Therapeutic applications
Transcription factors
Tumor suppressor genes
Tumorigenesis
Tumors
lung cancer subtypes
lung carcinoma
lung squamous cell carcinoma
mutated p53
p53
squamous cell carcinoma
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Summary:The gene is renowned as a tumor suppressor, playing a pivotal role in overseeing the cell cycle, apoptosis, and maintaining genomic stability. Dysregulation of p53 often contributes to the initiation and progression of various cancers, including lung cancer (LC) subtypes. The review explores the intricate relationship between p53 and its role in the development and progression of LC. p53, a crucial tumor suppressor protein, exists in various isoforms, and understanding their distinct functions in LC is essential for advancing our knowledge of this deadly disease. This review aims to provide a comprehensive literature overview of p53, its relevance to LC, and potential clinical applications.
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ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12071453