CAR T cells ignite antitumor immunity

• Published in: Trends in immunology Vol. 44; no. 10; pp. 748 - 750
• Main Authors: Alizadeh, Darya, Brown, Christine E.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.10.2023
• Subjects: antigen spreading; CAR T cell; chimeric antigen receptor (CAR); IFNgamma; myeloid cells; tumor heterogeneity; vaccine; chimeric antigen receptor (CAR); vaccine; CAR T cell; myeloid cells; IFNgamma; antigen spreading; tumor heterogeneity
• ISSN: 1471-4906; 1471-4981
• DOI: 10.1016/j.it.2023.08.002

Broadening immune responses through antigen spreading remains the ‘Holy Grail’ of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ. Broadening immune responses through antigen spreading remains the ‘Holy Grail’ of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.