STAT3 involvement in the acute phase-related expression of the rat haptoglobin gene

• Published in: Molecular biology reports Vol. 27; no. 2; p. 81
• Main Authors: Grigorov, I, Lazić, T, Cvetković, I, Milosavljević, T, Petrović, M
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.06.2000
• Subjects: Acute-Phase Proteins - genetics; Acute-Phase Proteins - metabolism; Acute-Phase Reaction - chemically induced; Acute-Phase Reaction - genetics; Animals; Base Sequence; Binding Sites; Cell Extracts; DNA - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Gene expression; Haptoglobins - genetics; Haptoglobins - metabolism; Hepatocytes - drug effects; Hepatocytes - metabolism; Liver; Liver - drug effects; Liver - metabolism; Male; Molecular biology; Molecular Sequence Data; Promoter Regions, Genetic; Rats; Rats, Wistar; Rodents; Signal transduction; STAT3 Transcription Factor; Trans-Activators - genetics; Trans-Activators - metabolism; Turpentine - toxicity

Turpentine-induced acute-phase (AP) response in rats is followed by transcriptional activation of the haptoglobin (Hp) gene in liver. Analysing the promoter sequence of the rat Hp gene we postulated an involvement of Signal Transducer and Activator of Transcription 3 (STAT3) in the regulation of thi...