Gabapentin‐induced coma in a patient with renal failure

We describe a 60‐year‐old woman who became comatose after a single dose of gabapentin for right‐sided sciatalgia. The patient was improved by hemodialysis. Gabapentin toxicity should be considered when mental status changes develop in patients with renal failure after even a single dose.

Saved in:
Bibliographic Details
Published inHemodialysis international Vol. 10; no. 2; pp. 168 - 169
Main Authors DOGUKAN, Ayhan, AYGEN, Bilge, BERILGEN, Muhammed S., DAG, Sait, BEKTAS, Sevim, GUNAL, Ali İ.
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.04.2006
Subjects
Administration, Oral
Amines - adverse effects
Amines - therapeutic use
coma
Coma - chemically induced
Coma - physiopathology
Cyclohexanecarboxylic Acids - adverse effects
Cyclohexanecarboxylic Acids - therapeutic use
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Gabapentin
gamma-Aminobutyric Acid - adverse effects
gamma-Aminobutyric Acid - therapeutic use
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - diagnosis
Middle Aged
renal failure
Risk Assessment
Sciatica - drug therapy
Sciatica - etiology
Online AccessGet full text

Cover

More Information
Summary:We describe a 60‐year‐old woman who became comatose after a single dose of gabapentin for right‐sided sciatalgia. The patient was improved by hemodialysis. Gabapentin toxicity should be considered when mental status changes develop in patients with renal failure after even a single dose.
ISSN:1492-7535
1542-4758
DOI:10.1111/j.1542-4758.2006.00089.x