Cutaneous metastases of papillary renal cell carcinoma: A case report and review of the literature

• Published in: Journal of cutaneous pathology Vol. 46; no. 12; pp. 960 - 964
• Main Authors: Cardwell, Leah A., Bender, Nicole R., Sokumbi, Olayemi
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2019; Wiley Subscription Services, Inc
• Subjects: Aged; Carcinoma, Papillary - pathology; Carcinoma, Renal Cell - complications; Carcinoma, Renal Cell - diagnostic imaging; Carcinoma, Renal Cell - pathology; Case reports; cutaneous metastases; Cytology; Dermis; Diagnosis, Differential; Fatal Outcome; Female; Humans; Kidney cancer; Kidney Neoplasms - pathology; Leukocytes (eosinophilic); Literature reviews; Male; Metastases; Metastasis; Middle Aged; Neoplasm Metastasis - immunology; Neoplasm Metastasis - pathology; papillary; Papillary renal cell carcinoma; Renal cell carcinoma; Skin Neoplasms - pathology; Skin Neoplasms - secondary; solid organ malignancy; Tumor cells; Tumors; solid organ malignancy; renal cell carcinoma; papillary; cutaneous metastases
• ISSN: 0303-6987; 1600-0560
• DOI: 10.1111/cup.13546

Papillary renal cell carcinoma (RCC) is an uncommon subtype of RCC that is typically encountered at early stages and has a high survival rate. Histopathology typically shows well‐defined papillary architecture with tumor cells lining fibrovascular cores and can be further subdivided into type 1 and type 2 tumors based on cytology and genetic basis. Type 1 tumors have a single layer of basophilic cells and low nuclear atypia, while type 2 tumors have a pseudostratified layer of eosinophilic cells and high nuclear atypia. Some tumors have overlapping features of both types. We present a unique case of cutaneous metastases of papillary RCC with typical papillary architecture in the dermis and review the literature on this rare entity.