A dose-response study of irritant reactions to sodium lauryl sulphate in patients with seborrhoeic dermatitis and atopic eczema

The susceptibility of the skin of patients with seborrhoeic dermatitis to surfactant irritation was investigated and compared to that of a group of normal subjects and patients with a history of atopic eczema. Responses to six concentrations of sodium lauryl sulphate (SLS), applied to forearm skin,...

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Published inActa dermato-venereologica Vol. 72; no. 6; pp. 432 - 435
Main Authors COWLEY, N. C, FARR, P. M
Format Journal Article
LanguageEnglish
Published Uppsala Acta dermato-venereologica 01.11.1992
Subjects
Adolescent
Adult
Biological and medical sciences
Blood Flow Velocity - drug effects
Dermatitis, Atopic - physiopathology
Dermatitis, Irritant - etiology
Dermatitis, Seborrheic - physiopathology
Dermatology
Dose-Response Relationship, Drug
Female
Humans
Male
Medical sciences
Skin - blood supply
Skin involvement in other diseases. Miscellaneous. General aspects
Sodium Dodecyl Sulfate
Human
Skin disease
Atopic dermatitis
Pathogenesis
Chemical compound
Hypersensitivity
Eczema
Irritant compound
Seborrheic dermatitis
Sebaceous gland
Dose activity relation
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Summary:The susceptibility of the skin of patients with seborrhoeic dermatitis to surfactant irritation was investigated and compared to that of a group of normal subjects and patients with a history of atopic eczema. Responses to six concentrations of sodium lauryl sulphate (SLS), applied to forearm skin, were assessed clinically and measured by laser Doppler flowmetry. Analysis of dose-response curves showed statistically significant increased susceptibility to SLS-induced irritation in patients with seborrhoeic dermatitis and atopic eczema compared with normal subjects. Increased susceptibility to chemical irritation may be important in the pathogenesis of seborrhoeic dermatitis.
ISSN:0001-5555
1651-2057
DOI:10.2340/0001555572432435