Effects of parathyroid hormone on sodium and calcium transport in the dog nephron

1. The effect of purified bovine parathyroid hormone on renal tubular reabsorption of sodium and calcium has been studied by micropuncture in intact and recently thyroparathyroidectomized dogs. 2. Parathyroid hormone increased the rejection of sodium and calcium proportionately at the late proximal...

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Bibliographic Details
Published inClinical science and molecular medicine Vol. 51; no. 4; p. 345
Main Authors Sutton, R A, Wong, N L, Dirks, J H
Format Journal Article
LanguageEnglish
Published England 01.10.1976
Subjects
Absorption
Animals
Calcium - metabolism
Dogs
Kidney - physiology
Kidney Tubules, Distal - physiology
Kidney Tubules, Proximal - physiology
Nephrons - physiology
Parathyroid Glands - surgery
Parathyroid Hormone - pharmacology
Sodium - metabolism
Thyroidectomy
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Summary:1. The effect of purified bovine parathyroid hormone on renal tubular reabsorption of sodium and calcium has been studied by micropuncture in intact and recently thyroparathyroidectomized dogs. 2. Parathyroid hormone increased the rejection of sodium and calcium proportionately at the late proximal tubule in both intact and operated dogs. 3. In both groups of dogs, there was increased delivery of sodium and calcium to the distal tubule after the hormone. However, the Ca/Na ratio decreased, suggesting some selective enhancement of calcium reabsorption before the superficial distal puncture site. 4. In the final urine, the Ca/Na ratio decreased highly significantly in both groups of dogs, indicating a further selective effect of parathyroid hormone on calcium reabsorption in or beyond the distal convoluted tubule.
ISSN:0301-0538
DOI:10.1042/cs0510345