Extracorporeal irradiation of tumorous calvaria. Case report

This patient with recurrent meningioma grossly involving the frontal bone underwent craniotomy and tumor resection. During the procedure a bone flap was irradiated extracorporeally at a very high dose (120 Gy) sufficient to sterilize residual tumor cells, and the bone was then successfully replaced...

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Bibliographic Details
Published inJournal of neurosurgery Vol. 93; no. 3; p. 494
Main Authors Manning, M A, Cardinale, R M, Schmidt-Ullrich, R K, Kavanagh, B D, Wornom, 3rd, I L, Broaddus, W C
Format Journal Article
LanguageEnglish
Published United States 01.09.2000
Subjects
Craniotomy
Humans
Male
Meningeal Neoplasms - pathology
Meningeal Neoplasms - radiotherapy
Meningeal Neoplasms - surgery
Meningioma - pathology
Meningioma - radiotherapy
Meningioma - surgery
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Skull - transplantation
Skull Neoplasms - pathology
Skull Neoplasms - radiotherapy
Skull Neoplasms - surgery
Surgical Flaps
Transplantation, Autologous
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Summary:This patient with recurrent meningioma grossly involving the frontal bone underwent craniotomy and tumor resection. During the procedure a bone flap was irradiated extracorporeally at a very high dose (120 Gy) sufficient to sterilize residual tumor cells, and the bone was then successfully replaced orthotopically for reconstruction. The use of autologous irradiated bone in this setting offers advantages over cadaveric transplantation and prosthetic implants. Radiation might cause less disruption of the bone's architecture than other techniques of tumor cell eradication.
ISSN:0022-3085
DOI:10.3171/jns.2000.93.3.0494