Cell Attachment on Inside-Outside Surface and Cell Encapsulation in Wall of Microscopic Tubular Scaffolds for Vascular Tissue-Like Formation

By using the microfluidic spinning technology we generated tiny hydrogel tubular scaffolds. Fibroblast (NIH/3T3) cell cultures were performed for seventeen days to demonstrate the potential of cell attachment on surfaces and encapsulation in the wall of he microscopic scaffolds for blood vessel-like...

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Published in2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Vol. 2018; pp. 4198 - 4201
Main Authors Duong, Van Thuy, Son, Hyewon, Jang, Hojeong, Oh, Seok, Back, Sung Hoon, Hwang, Changho, Koo, Kyoin, Dang, Thi Thao, Lee, Yeasol, Nguyen, Chanh Trung, Phan, Huu Lam, Shin, Daehyeon, Lee, YongKwan, Park, Hodong, Lee, HyoSeok
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States IEEE 01.07.2018
Subjects
Blood
Generators
Glass
Microfluidics
Microscopy
Sodium
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Summary:By using the microfluidic spinning technology we generated tiny hydrogel tubular scaffolds. Fibroblast (NIH/3T3) cell cultures were performed for seventeen days to demonstrate the potential of cell attachment on surfaces and encapsulation in the wall of he microscopic scaffolds for blood vessel-like structure forming. Over theculture period, the NIH/3T3 confluence reached around 80%, and 100% on the inside and outside scaffolds' surface respectively while cells proliferated and coalesced in cell group in the hydrogel wall. These results could further be applied to endothelial co-culturing for forming engineered blood vessel.
ISSN:1557-170X
1558-4615
DOI:10.1109/EMBC.2018.8513248