Polyaniline electrospinning composite fibers for orthotopic photothermal treatment of tumors in vivo

A nanocomposite fabricated by electrostatic spinning, which incorporated polyaniline nanoparticles into poly( -caprolactone) and gelatin (PG), was used to form nanofiber fabrics. Polyaniline nanoparticles have a strong optical absorption at near-infrared (NIR) wavelengths and can convert optical ene...

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Bibliographic Details
Published inNew journal of chemistry Vol. 39; no. 6; pp. 4987 - 4993
Main Authors Chen, Yinyin, Li, Chunxia, Hou, Zhiyao, Huang, Shanshan, Liu, Bei, He, Fei, Luo, Laoyong, Lin, Jun
Format Journal Article
LanguageEnglish
Published 01.01.2015
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Summary:A nanocomposite fabricated by electrostatic spinning, which incorporated polyaniline nanoparticles into poly( -caprolactone) and gelatin (PG), was used to form nanofiber fabrics. Polyaniline nanoparticles have a strong optical absorption at near-infrared (NIR) wavelengths and can convert optical energy into thermal energy under 808 nm laser irradiation, allowing them to ablate tumor cells thermally. Pieces of the nanocomposite were surgically implanted into tumors in mice, and orthotopic photothermal therapy was performed. The experimental results in vivo suggested that polyaniline PG can inhibit tumor growth efficiently by converting optical energy into thermal energy to ablate tumor cells. Electrospun nanocomposite fiber fabric, consisting of polyaniline nanoparticles, poly( -caprolactone), and gelatin, efficiently inhibited tumor growth in vivo by orthotopic photothermal treatment.
ISSN:1144-0546
1369-9261
DOI:10.1039/c5nj00327j