Sigma-1 Receptor Antagonist Haloperidol Attenuates Store-Dependent Ca2+ Entry in Macrophages

Using Fura-2AM microfluorimetry, we have shown for the first time that preincubation of macrophages with sigma-1 receptor antagonist haloperidol leads to a significant inhibition of the store-dependent Ca 2+ entry induced by endoplasmic Ca 2+ -ATPase inhibitors thapsigargin or cyclopiazonic acid in...

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Published inDoklady. Biochemistry and biophysics Vol. 480; no. 1; pp. 162 - 165
Main Authors Krutetskaya, Z. I., Milenina, L. S., Naumova, A. A., Butov, S. N., Antonov, V. G., Nozdrachev, A. D.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.05.2018
Springer Nature B.V
Subjects
Adenosine triphosphatase
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Ca2+-transporting ATPase
Calcium influx
Cyclopiazonic acid
Haloperidol
Life Sciences
Macrophages
Molecular Biology
Peritoneum
Thapsigargin
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Summary:Using Fura-2AM microfluorimetry, we have shown for the first time that preincubation of macrophages with sigma-1 receptor antagonist haloperidol leads to a significant inhibition of the store-dependent Ca 2+ entry induced by endoplasmic Ca 2+ -ATPase inhibitors thapsigargin or cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of the sigma-1 receptor in the regulation of storedependent Ca 2+ entry in macrophages.
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ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672918030109