Plasma and urine dopamine in man given sodium chloride in the diet

1. Plasma and urine free dopamine were measured daily for 5 days in six normal subjects maintained on a low sodium diet. The subjects were then given dietary supplements of sodium chloride for 5 days and the measurements repeated. 2. Throughout the experiment the 24 h free dopamine excretion rates f...

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Bibliographic Details
Published inClinical science (1979) Vol. 56; no. 3; pp. 261 - 264
Main Authors Oates, N S, Ball, S G, Perkins, C M, Lee, M R
Format Journal Article
LanguageEnglish
Published England 01.03.1979
Subjects
Creatinine - metabolism
Dopamine - blood
Dopamine - metabolism
Dopamine - urine
Humans
Male
Renin - blood
Sodium - urine
Sodium Chloride
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Summary:1. Plasma and urine free dopamine were measured daily for 5 days in six normal subjects maintained on a low sodium diet. The subjects were then given dietary supplements of sodium chloride for 5 days and the measurements repeated. 2. Throughout the experiment the 24 h free dopamine excretion rates for all the subjects were higher than could be accounted for by renal clearance. Dopamine excretion increased significantly in response to the added sodium chloride whereas plasma dopamine remained unchanged. The rise in dopamine excretion preceded that of sodium excretion. 3. It is concluded that free dopamine is formed within the kidney in response to increased dietary sodium and may have a role in the control of sodium excretion.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0143-5221
1470-8736
DOI:10.1042/cs0560261