A COMPARATIVE EVALUATION OF ROPIVACAINE HYDROCHLORIDE AND ROPIVACAINE HYDROCHLORIDE WITH DEXMEDETOMIDINE FOR CAUDAL EPIDURAL ANAESTHESIA IN PAEDIATRIC PATIENTS UNDERGOING ELECTIVE INFRAUMBILICAL SURGERIES

• Published in: Journal of evolution of medical and dental sciences Vol. 6; no. 14; pp. 1072 - 1076
• Main Authors: Goyal, Preeti, Yadav, Satyendra Singh, Ranjan, Priya, Chaudhary, Bhanu, Chorasia, H.K, Mathur, Ashish, Jain, V.K.D
• Format: Journal Article
• Language: English
• Published: Akshantala Enterprises Private Limited 16.02.2017
• Subjects: Anesthetics; Comparative analysis; Complications and side effects; Dexmedetomidine; Dosage and administration; Drug therapy; Pain management; Pediatric surgery; Postoperative pain
• ISSN: 2278-4748; 2278-4802
• DOI: 10.14260/jemds/2017/232

BACKGROUND The aim of this study is to compare the efficacy of ropivacaine hydrochloride and ropivacaine hydrochloride with dexmedetomidine in caudal epidural anaesthesia for postoperative pain relief in paediatric patients undergoing elective infraumbilical surgeries. MATERIALS AND METHODS A prospective randomised study was carried out, which included sixty paediatric patients between the ages of 2-8 years of ASA Grade I/II patients who underwent infraumbilical surgeries. Patients were randomly divided into two Groups R and RD of thirty patients each. Group R received ropivacaine 0.2% 1 mL/kg with 0.5 mL normal saline, while Group RD received ropivacaine 0.2% 1 mL/kg with dexmedetomidine 2 mcg/kg diluted to 0.5 mL of normal saline. Duration of analgesia, duration of motor blockade, sedation and side effects were observed. The data obtained was subjected to statistical computation with analysis of variance and chi-square test using Statistical Package for Sciences (SPSS) version 10 for windows and value of P < 0.05 was considered significant and P < 0.001 as highly significant. RESULTS The demographic profile, intra- and post-operative block characteristics and cardiorespiratory parameters were comparable and non-significant in both the groups. However, duration of postoperative analgesia is significantly prolonged in RD group as compared to R group. Sedation score with dexmedetomidine were better and turned out to be statistically significant. Side effect profile was also comparable. CONCLUSION Dexmedetomidine is a better neuraxial adjuvant for providing adequate sedation and prolonged post-operative analgesia. KEYWORDS Dexmedetomidine, Ropivacaine, Caudal, Epidural, Paediatric, Infraumbilical.