Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barre syndrome

Guillain-Barre syndrome is a postinfectious, autoimmune neuropathy resulting in neuromuscular paralysis. Auto-antibodies, often induced by bacterial infection, bind to human gangliosides possessing monosialoside and diasialoside epitopes and impair the function of nerve junctions, where these gangli...

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Published inOrganic & biomolecular chemistry Vol. 2; no. 8; pp. 1199 - 1212
Main Authors Andersen, SM, Ling, CC, Zhang, P, Townson, K, Willison, HJ, Bundle, DR
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.04.2004
Subjects
Antibodies, Monoclonal - immunology
Antigen-Antibody Reactions
Carbohydrate Sequence
Chemistry
Chemistry, Organic
G(M2) Ganglioside - chemical synthesis
G(M2) Ganglioside - therapeutic use
Gangliosides - chemical synthesis
Gangliosides - therapeutic use
Guillain-Barre Syndrome - immunology
Guillain-Barre Syndrome - therapy
Humans
Immunosorbent Techniques
Immunosorbents - pharmacology
Ligands
Molecular Sequence Data
Neuromuscular Nondepolarizing Agents - chemical synthesis
Neuromuscular Nondepolarizing Agents - therapeutic use
Oligosaccharides - immunology
Physical Sciences
Science & Technology
CAMPYLOBACTER-JEJUNI LIPOPOLYSACCHARIDES
ANTIBODIES
CHEMICAL STRUCTURES
ACID
MILLER-FISHER-SYNDROME
REGIONS
ATAXIC NEUROPATHY
IGG
MOLECULAR MIMICRY
GD
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Summary:Guillain-Barre syndrome is a postinfectious, autoimmune neuropathy resulting in neuromuscular paralysis. Auto-antibodies, often induced by bacterial infection, bind to human gangliosides possessing monosialoside and diasialoside epitopes and impair the function of nerve junctions, where these ganglioside structures are highly enriched. Truncated gangliosides representive of GD(3), GQ(1b) and GM(2) epitopes have been synthesized as methyl glycosides and as a glycosides of an eleven carbon tether. The synthetic oligosaccharide ligands are structural mimics of these highly complex ganglioside epitopes and via their ability to neutralize or remove auto-antibodies have the potential for therapy, either as soluble blocking ligands administered systemically, or as immuno-affinity ligands for use as extracorporeal immunoadsorbents.
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ISSN:1477-0520
1477-0539
DOI:10.1039/b400029c