Detection of endogenous hormones and its effect on auxiliary medical treatment

• Published in: Biosensors and bioelectronics. X Vol. 18; p. 100477
• Main Authors: Yu, Jiayu, Wang, Qilin, Chen, Yinchao, Ouyang, Yizhen, Xu, Haitao
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2024; Elsevier
• Subjects: Auxiliary medical treatment; Biosensors; Endogenous hormones; Biosensors; Endogenous hormones; Auxiliary medical treatment
• ISSN: 2590-1370; 2590-1370
• DOI: 10.1016/j.biosx.2024.100477

The detection of endogenous hormones is of great significance for disease diagnosis, treatment guidance, and the development of personalized healthcare. By using biosensors, real-time monitoring and quantitative analysis of endogenous hormone levels can be achieved, providing scientific basis for clinical decision-making. The continuous innovation in this field will bring new breakthroughs in medical diagnosis and treatment, which are expected to accelerate the early detection of diseases and the implementation of personalized treatment plans. In this review, we mainly review the research progress of endogenous hormone biosensors based on different biological recognition elements, namely enzyme-based biosensors, immunobiosensors, aptamer-based biosensors, and molecularly imprinted polymer (MIP) based biosensors. Meanwhile, this paper also analyzes the detection efficiency and clinical application of these biosensors. Finally, we summarize the current challenges and future development directions of the different types of biosensors involved in the discussion. •Recent achievements in biosensor development for endogenous hormone detection.•Comprehensive understanding of the specific properties of enzyme biosensors, immune biosensors, aptamer biosensors, and MIP biosensors.•Performance evaluation of the biosensors and explanation of their synergistic mechanism.