A Novel Method to Classify the Responses of Genioglossus to Negative Pressure in OSA Patients

• Published in: Otolaryngology-head and neck surgery Vol. 170; no. 2; p. 586
• Main Authors: Zhou, Yingqian, Yin, Guoping, Xu, Jinkun, Cao, Xin, Ye, Jingying
• Format: Journal Article
• Language: English
• Published: England 01.02.2024
• Subjects: Cohort Studies; Electromyography; Humans; Prospective Studies; Sleep - physiology; Sleep Apnea, Obstructive - surgery; Tongue; obstructive sleep apnea; neuromuscular response; drug-induced sleep endoscopy; genioglossus; negative upper airway pressure
• ISSN: 1097-6817
• DOI: 10.1002/ohn.525

This study aims to develop a novel method to classify different genioglossus (GG) responses to upper airway (UA) negative pressure in obstructive sleep apnea (OSA) patients. A single-center, prospective, cohort study. Sleep Medical Center. Patients with OSA underwent drug-induced sleep endoscopy with synchronous genioglossus electromyography (ggEMG) and UA pressure monitoring. In spontaneous obstructive apnea events, the value of epiglottis negative pressure at the end of inspiration (P ) and corresponding peak phasic ggEMG were recorded as pairing data for linear regression analysis to classify GG response modes: peak phasic ggEMG-P linear mode (P < .05) were classified as group 1; others (P ≥ .05) were classified as group 2. Using nasopharyngeal tube (NPT) to reopen the palatopharyngeal cavity for comparing the improvement between the OSA patients with different GG response modes. Sixty subjects were analyzed for GG response modes: 22 patients were in group 1 (r  = 0.233-0.867), and 38 patients were in group 2. The proportion of partial (63.16% vs 59.09%) or complete (36.84% vs 22.73%) collapse rate of the tongue base in group 2 was significantly higher (χ  = 7.823, P = .020). The improvement of the apnea-hypopnea index after NPT placement in group 2 was significantly lower than in group 1 (59.09% vs 31.58%, χ  = 4.339, P = .037). This novel method is advantageous for distinguishing OSA patients with different GG response abilities to UA negative pressure, whose GG responses conforming to peak phasic ggEMG-P linear mode might be more suitable for palatopharyngeal surgery.