Prevalence rates study of selected isolated non‐Mendelian congenital anomalies in the Hutterite population of Alberta, 1980–2016

• Published in: American journal of medical genetics. Part A Vol. 182; no. 11; pp. 2594 - 2604
• Main Authors: Lowry, R. Brian, Bedard, Tanya, Crawford, Susan, Grevers, Xin, Bernier, François P., Thomas, Mary Ann
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2020; Wiley Subscription Services, Inc
• Subjects: Cardiovascular disease; Cleft lip/palate; congenital anomalies; Congenital defects; Congenital diseases; Hutterites; non‐Mendelian; prevalence; Spina bifida; Statistical analysis; Tetralogy of Fallot; Tricuspid atresia; non-Mendelian; Hutterites; prevalence; congenital anomalies
• ISSN: 1552-4825; 1552-4833
• DOI: 10.1002/ajmg.a.61834

A study of the prevalence rates for selected isolated non‐Mendelian congenital anomalies in the Hutterite Brethren of Alberta, Canada was undertaken to further examine longitudinal data in this isolated community that was last reported in 1985 (Lowry et al., 1985), although there are numerous publications on recessive disorders (Boycott et al., 2008; Triggs‐Raine et al., 2016). Cases were ascertained from the Alberta Congenital Anomaly Surveillance System for the years 1997–2016. Since our initial results showed some surprising findings in the Hutterite Brethren, such as zero cases of spina bifida, cleft lip and palate, gastroschisis, and omphalocele, and a significant excess of cases with hypospadias, we extended the study to prior years (1980–1996) for selected anomalies. For the extended study period (1980–2016), there was a significant increased prevalence of hypospadias, tetralogy of Fallot and tricuspid atresia in the Hutterite population, and although not statistically significant, zero cases of cleft lip with cleft palate, gastroschisis and omphalocele were confirmed. Further research is needed to determine the precise effects of rural environmental exposures, lifestyle factors, and genetic associations for selected multifactorial congenital anomalies.